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Article History

Received: 14 September 2018

Accepted: 29 March 2019

First Online: 16 April 2019

Ethics approval and consent to participate

: The study was approved by the local Medical Ethical Committee. All patients provided written informed consent for their clinical data to be used for research purposes.

: Not applicable.

: Dr. Prins serves on the advisory board of Boehringer Ingelheim and Probiodrug and on the DSMB of Abbvie’s M15-566 trial. He has provided consultancy services for Sanofi, Takeda, and Kyowa Kirin Pharmaceutical Development. NDP is the CEO and co-owner of the Alzheimer Research Center, Amsterdam, the Netherlands.C. Teunissen serves on the advisory board of Fujirebio and Roche, received research consumables from Euroimmun, IBL, Fujirebio, Invitrogen, and Mesoscale Discovery; performed contract research for IBL, Shire, Boehringer, Roche, and Probiodrug; and received grants from the European Commission, the Dutch Research Council (ZonMW), Association of Frontotemporal Dementia/Alzheimer’s Drug Discovery Foundation, ISAO, and the Alzheimer’s Drug Discovery Foundation.Dr. Scheltens has acquired grant support (for the institution) from GE Healthcare, Danone Research, Piramal, and MERCK. In the past 2 years, he has received consultancy/speaker fees (paid to the institution) from Lilly, GE Healthcare, Novartis, Sanofi, Nutricia, Probiodrug, Biogen, Roche, Avraham, and EIP Pharma.Dr. Barkhof serves as a consultant for Biogen-Idec, Janssen Alzheimer Immunotherapy, Bayer-Schering, Merck-Serono, Roche, Novartis, Genzume, and Sanofi-aventis; has received sponsoring from EU-H2020, NIHR-UCLH, NOW, SMSR, TEVA, Novartis, Toshiba; and serves on the editorial boards of Radiology, Brain, Neuroradiology, MSJ, and Neurology.Dr. Peters is on scientific advisory boards for Roche, Kyowa Kirin, Novartis, Lilly, and Piramal. He has received funding for travel or speaker honoraria from GSK, Nutricia, and Merck Serono. He has acted as a consultant for Affiris and Roche. He has received research support from Affiris, Piramal, BMS, Eli Lilly, Pfizer, Servier, TRX Pharmaceuticals, Lundbeck, and Genentech.Dr. Jessen has received consultation board honoraria and speakers fees from AC Immune, Lilly, GE Healthcare, Janssen, USB, Schwabe, Esai, Pfizer, Novartis, and Roche. He has received a research grant paid to his institution from Schwabe.Dr. van der Flier performs contract research for Biogen MA Inc. Research programs of W.M.v.d.F. have been funded by ZonMW, NWO, EU-FP7, EU-JPND, Alzheimer Nederland, Cardiovasculair Onderzoek Nederland, Stichting Dioraphte, Gieskes-Strijbis Fonds, Boehringer Ingelheim, Piramal Neuroimaging, Roche BV, Janssen Stellar, and Combinostics. All funding is paid to her institution.van Maurik, Slot, Verfaillie, Dr. Zwan, Dr. Bouwman, Dr. Wattjes, Dr. Wolfsgruber, and Dr. Berkhof declare that they have no competing interests.

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