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Article History

Received: 4 May 2020

Accepted: 9 September 2020

First Online: 2 October 2020

Ethics approval and consent to participate

: Fundació ACE cohort has been approved by the ethic committee of the Hospital Clinic i Provincial de Barcelona in Barcelona, Spain, in accordance with Spanish biomedical laws (Law 14/2007, July 3rd, about biomedical research; Royal Decree 1716/2011, November 18th) and followed the recommendations of the Declaration of Helsinki.

: All the samples from the Fundació ACE cohort and the Heidelberg/Mannheim memory clinic have the informed consent of the subjects that have donated them. In the Fundació ACE cohort, these protocols of consent have been approved previously by Ethics Committee of the Hospital Clínic (HCB/2014/0494, HCB/2016/0571, HCB/2016/0835, HCB/2017/0125, and HCB/2018/0333). The protocols have been designed in agreement with the indications of the Sociedad Española de Neurologiaaccording to the current normative for the use of clinical data and biological material and surplus of the assisted process for the biomedicine research of neurodegenerative diseases.

: S.A., A.O., I.K., L.F., I.R., S.G., M.B., I.H., L.H., N.A., A.R., A.R., T.H., and C.M.D declared no competing interests. Margot H.M. Bakker is a full-time employee of AbbVie Deutschland GmbH & Co KG and owns AbbVie stock. Alfredo Cabrera-Socorro is full-time employee of Janssen Pharmaceutical NV, Turnhoutseweg 30, 2340 Beerse, Belgium.