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Article History

Received: 17 November 2020

Accepted: 23 December 2020

First Online: 7 January 2021

Ethics approval and consent to participate

: We obtained written informed consent from all patients. The study was approved by the Medical Ethics Review Committee of the VU University Medical Center.

: Not applicable.

: Ingrid S. van Maurik reports no financial disclosures or conflicts of interest.Hanneke F.M. Rhodius-Meester performs contract research for Combinostics, and all funding is paid to her institution.Charlotte E. Teunissen has a collaboration contract with ADx Neurosciences and Quanterix, performed contract research, or received grants from AxonNeurosciences, Biogen, Boehringer, Brainstorm Therapeutics, EIP farma, Esai, Janssen prevention center, Roche, Toyama, Vivoryon.Philip Scheltens reports, outside the submitted work, support from Novartis NOVARTIS, GENENTECH, AC IMMUNE, AXON NEUROSCIENCE, EIP PHARMA, COGRX GEMVAX, CORTEXZYME, GREEN VALLEY, COGNOPTIX.P.S. has acquired grant support (for the institution) from GE Healthcare, Danone Research, Piramal and Merck. In the past 2 years, he has received consultancy/speaker fees (paid to the institution) from Lilly, GE Healthcare, Novartis, Sanofi, Nutricia, Probiodrug, Biogen, Roche, Avraham, and EIP Pharma.Frederik Barkhof is supported by the NIHR biomedical research centre at UCLH.Sebastian Palmqvist reports no financial disclosures or conflicts of interest.Oskar Hansson has acquired research support (for the institution) from Roche, Pfizer, GE Healthcare, Biogen, Eli Lilly, and AVID Radiopharmaceuticals. In the past 2 years, he has received consultancy/speaker fees (paid to the institution) from Biogen and Roche.Wiesje M. van der Flier: Research programs of Wiesje van der Flier have been funded by ZonMW, NWO, EU-FP7, EU-JPND, Alzheimer Nederland, CardioVascular Onderzoek Nederland, Health~Holland, Topsector Life Sciences & Health, stichting Dioraphte, Gieskes-Strijbis fonds, stichting Equilibrio, Pasman stichting, Biogen MA Inc., Boehringer Ingelheim, Life-MI, AVID, Roche BV, Fujifilm, Combinostics. WF holds the Pasman chair. WF has performed contract research for Biogen MA Inc. and Boehringer Ingelheim. WF has been an invited speaker at Boehringer Ingelheim and Biogen MA Inc. All funding is paid to her institution.Johannes Berkhof reports no financial disclosures or conflicts of interest.