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Article History

Received: 5 November 2021

Accepted: 5 March 2022

First Online: 19 April 2022

Declarations

:

: Not applicable.

: Not applicable.

: SSA is a full-time employee of Genentech and receives salary and bonuses, and owns company stock.RAS reports grants from NIH, research funding from Alzheimer’s Association, Janssen, Eli Lilly, and Eisai. She reports receiving personal fees from AC Immune, Acumen, Alnylam, Cytox, Genentech, Janssen, JOMDD, Nervgen, Neuraly, Neurocentria, Oligomerix, Prothena, Renew, Shionogi, and Vigil Neuroscience.CR has been a paid consultant for several companies developing treatments for Alzheimer’s disease over the last 5 years including Biogen, Eli Lilly, Merck, Roche, Janssen, Abbvie, Kyowa Kirin, Actinogen, and Eisai. He was the UK Chief Investigator for the ENGAGE Trial and Academic Lead on the EPAD (European Prevention of Alzheimer’s Dementia) Programme, which was a public:private partnership between the EU and several companies with an interest in developing treatments for AD ExternalRef removed. His unit at the University of Edinburgh (Edinburgh Dementia Prevention) has received grant funding from Biogen, Janssen, AC Immune, and Actinogen. He is the unpaid chairperson of the Brain Health Clinic Consortium established in the UK by Biogen.DRK has nothing to disclose.PSA reports research agreements with Janssen, Lilly and Eisai; grants from NIA, the Alzheimer’s Association, and FNIH and consulting fees from Biogen, Roche, Merck, Abbvie, Immunobrain Checkpoint, Rainbow Medical, and Shionogi.CL is a full-time employee and shareholder of F. Hoffmann-La Roche Ltd.AA reports receiving grants to his institution for clinical trials and research from NIA/NIH, Alzheimer’s Clinical Trials Consortium, Alzheimer's Disease Cooperative Study, Alzheimer’s Therapeutics Research Institute, American College of Radiology, Arizona Alzheimer’s Research Consortium, Alzheimer's Prevention Initiative, Biohaven, Global Alzheimer’s Platform, Johns Hopkins, Lilly, NIH/NIA, University of Indiana, University of Southern California, Athira, Alzheon, and Gates Ventures. He reports having received personal fees from AbbVie, Acadia, Allergan, Axovant, AZTherapies, Biogen, Eisai, Grifols, the Japanese Organization for Medical Device Development, Medical Care Corporation, Lundbeck, Merck, Novo Nordisk, Roche/Genentech, Sunovion, Suven, and Synexus. Dr. Atri receives book royalties from Oxford University Press.JC has provided consultation to AB Science, Acadia, Alkahest, AlphaCognition, ALZPath, Annovis, AriBio, Artery, Avanir, Biogen, Biosplice, Cassava, Cerevel, Clinilabs, Cortexyme, Diadem, EIP Pharma, Eisai, GatehouseBio, GemVax, Genentech, Green Valley, Grifols, Janssen, Karuna, Lexeo, Lilly, Lundbeck, LSP, Merck, NervGen, Novo Nordisk, Oligomerix, Otsuka, PharmacotrophiX, PRODEO, Prothena, ReMYND, Renew, Resverlogix, Roche, Signant Health, Suven, Unlearn AI, Vaxxinity, VigilNeuro, Zai Laboratories pharmaceutical, assessment, and investment companies. Dr Cummings is supported by NIGMS grant P20GM109025; NINDS grant U01NS093334; NIA grant R01AG053798; NIA grant P20AG068053; NIA grant R35AG71476; the Alzheimer’s Disease Drug Discovery Foundation (ADDF); and the Joy Chambers-Grundy Endowment. Dr. Cummings has copyright on the Neuropsychiatric Inventory (NPI).