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Proximity extension assay in cerebrospinal fluid identifies neurofilament light chain as biomarker of neurodegeneration in sporadic cerebral amyloid angiopathy

Crossref DOI link: https://doi.org/10.1186/s13195-024-01473-0

Published Online: 2024-05-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Vervuurt, Marc

Kuiperij, H. Bea

de Kort, Anna M.

Kersten, Iris

Klijn, Catharina J. M.

Schreuder, Floris H. B. M.

Verbeek, Marcel M.
Funding

Funding for this research was provided by:

National Institutes of Health (5R01NS104147-02, 5R01NS104147-02, 5R01NS104147-02, 5R01NS104147-02, 5R01NS104147-02)

ZonMw (733050822, 733050822, 733050822, 733050822, 733050822, 733050822)
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Article History

Received: 21 December 2023

Accepted: 1 May 2024

First Online: 14 May 2024

Declarations

:

: Lumbar punctures were performed after informed consent from the patients themselves or from the patients’ legal representatives. Most participants underwent lumbar punctures in the context of cohort studies on biomarkers. All sCAA patients were included from the CAVIA (no. 733,050,202) and BIONIC (nr. 733,050,822) studies. Most control participants were included from the CAFE study (nr. 5R01NS104147-02), while some were included in the context of a routine diagnostic clinical work-up. This study was approved by the Medical Ethics Committee Arnhem-Nijmegen.

: Not applicable.

: The authors declare they have no competing interests.

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