Yaqub, Amber
Vojinovic, Dina
Vernooij, Meike W.
Slagboom, P. Eline
Ghanbari, Mohsen
Beekman, Marian
van der Grond, Jeroen
Hankemeier, Thomas
van Duijn, Cornelia M.
Ikram, M. Arfan
Ahmad, Shahzad
Funding for this research was provided by:
Deltaplan Dementie from ZonMW Memorabel (73305095005)
Article History
Received: 23 October 2023
Accepted: 13 May 2024
First Online: 20 May 2024
Declarations
:
: The Rotterdam Study has been approved by the Medical Ethics Committee of the Erasmus University Medical Center (registration number MEC 02.1015) according to the Population Screening Act, executed by the Dutch Ministry of Health, Welfare and Sport (license number 1071272-159531-PG). All participants provided written informed consent. The Leiden Longevity Study has been approved by the ethical committee of the Leiden University Medical Center before the start of the study (P01.113). In accordance with the Declaration of Helsinki, all participants prior to their entering the study provided informed consent. Good clinical practice guidelines were maintained.
: Not applicable.
: The authors declare no competing interests.
: @ErasmusMC: In the population-based Rotterdam Study, associations were explored between plasma TMAO & its precursors with cognition, neuroimaging markers and dementia. Notably, higher levels of plasma choline were linked to cognitive impairment, brain atrophy and markers of cerebral small vessel disease. This research underscores the complex dynamics of the gut-brain axis and the crucial need for further studies in this field. #GutMicrobiome #Neuroimaging #DementiaResearch.
: Not applicable.