Jiang, Jiwei
Zhuo, Zhizheng
Wang, Anxin
Li, Wenyi
Jiang, Shirui
Duan, Yunyun
Ren, Qiwei
Zhao, Min
Wang, Linlin
Yang, Shiyi
Awan, Maher Un Nisa
Liu, Yaou
Xu, Jun
Funding for this research was provided by:
National Key Research and Development Program of China (2021YFC2500100 and 2021YFC2500103)
National Natural Science Foundation of China (82071187 and 81870821)
Article History
Received: 17 January 2024
Accepted: 25 June 2024
First Online: 3 July 2024
Declarations
:
: This study utilized prospectively collected data from the Chinese Imaging, Biomarkers, and Lifestyle (CIBL) study between January 1, 2021, and December 31, 2022, which was approved by the Institutional Review Board of Capital Medical University, Beijing Tiantan Hospital (Beijing, China; KY-2021-028-01) and registered at Chictr.org.cn (ChiCTR2100049131). All participants or their caregivers provided written informed consent.
: All participants or their caregivers provided written informed consent for the publication.
: The authors declare no competing interests.
: Activities of Daily Living (ADL).Alzheimer’s disease (AD).Blood–brain barrier (BBB).Body mass index (BMI).Cerebrospinal fluid (CSF).Cortical thickness (CT).Choroid plexus (ChP).Corrected cerebral blood flow (cCBF).Chinese Imaging, Biomarkers, and Lifestyle (CIBL).Healthy controls (HCs).Mild cognitive impairment (MCI).Mini-Mental State Examination (MMSE).Montreal Cognitive Assessment (MoCA).Neuropsychiatric Inventory (NPI).Natural direct effects (NDEs).Natural indirect effects (NIEs).Receiver operating characteristic (ROC).Gray matter (GM).White matter hypointensity (WMH).Total effect (TE).