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Article History

Received: 22 April 2025

Accepted: 14 July 2025

First Online: 25 July 2025

Declarations

:

: The investigators agreed to conduct the human study according to the principles of the ICH guideline E6: Good Clinical Practice. The investigators performed all aspects of this study in accordance with the ethical principles that have their origin in the Declaration of Helsinki, the study protocol, and all national, state, and local laws or regulations. The original study protocol and protocol amendments were approved by the Advarra investigators’ institutional review boards (sites: PPD Development, LP; Quotient Sciences). For animal studies, all experimental procedures were conducted according to the approved protocols from the relevant institutions: nonhuman primate study, Covance Laboratories Inc. #8389798; rat study, Covance Laboratories Inc. #8398801. All procedures complied with the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the Office of Laboratory Animal Welfare.

: Not applicable.

: Ba.B., L.P., A.M., H.L., N.B-L., W.E., Br.B., G.C., S.K-M., and A.R. are employees of Alector, Inc. and may have an equity interest in Alector, Inc. M.K., T.S., and R.P. were employees of Alector at the time of manuscript conception and may have an equity interest in Alector, Inc.