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Authors
Ritchie, Marina
Hussen, Kedir
Langford, Oliver
Navarro, Christian
Kotadiya, Zara
Donohue, Michael C.
Aisen, Paul
Sperling, Reisa A.
Grill, Joshua D.
Raman, Rema
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Article History
Received: 19 June 2025
Accepted: 7 September 2025
First Online: 14 October 2025
Declarations
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: The A4 Study was conducted in accordance with International Council for Harmonisation Good Clinical Practice guidelines. Each A4 site obtained approval from their local institutional review board. The participants screening for the A4 Study provided permission to share their de-identified data to permit secondary analyses such as those in this study.
: Participants in A4 provided consent for the publication of de-identified data, such as those reported in this study.
: MCD’s spouse is a fulltime employee of Janssen Pharmaceuticals. RAS has served as a consultant for AbbVie, AC Immune, Acumen, Alector, Apellis, Biohaven, Bristol Myers Squibb, Genentech, Ionis, Janssen, Oligomerix, Prothena, Roche, and Vaxxinity over the past 3 years. She has received research funding from Eisai and Eli Lilly for public-private partnership clinical trials and receives research grant funding from the National Institute on Aging/National Institutes of Health, GHR Foundation, and the Alzheimer’s Association. Her spouse, K. Johnson, reports consulting fees from Novartis, Merck, and Janssen. Other authors declare that they have no competing interests.
