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Double cutoff strategies for plasma pTau217 to predict Tau PET positivity across multiple assay platforms: Tau-enriched and Tau-scarce cohorts for cost-effective clinical use

Crossref DOI link: https://doi.org/10.1186/s13195-025-01952-y

Published Online: 2026-01-14

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kang, Heekyoung https://orcid.org/0000-0003-0287-6818
Gu, Yuna https://orcid.org/0009-0007-3200-3977
Lee, Jungah https://orcid.org/0000-0003-4989-9670
Yoon, Soyeon

Zetterberg, Henrik https://orcid.org/0000-0003-3930-4354
Blennow, Kaj https://orcid.org/0000-0002-1890-4193
Gonzalez-Ortiz, Fernando https://orcid.org/0000-0001-7897-9456
Ashton, Nicholas J. https://orcid.org/0000-0002-3579-8804
Day, Theresa A. https://orcid.org/0009-0008-7321-6183
Weiner, Michael W. https://orcid.org/0000-0002-0144-1954
Shin, Daeun https://orcid.org/0000-0003-4834-1026
Yim, Sohyun https://orcid.org/0000-0002-9357-768X
Kim, Seonghyeon https://orcid.org/0009-0006-3288-851X
Park, Hee Kyung https://orcid.org/0000-0001-6339-0059
Chun, Min Young https://orcid.org/0000-0003-3731-6132
Lee, Eun Hye https://orcid.org/0000-0002-4206-6214
Kim, Jun Pyo https://orcid.org/0000-0003-4376-3107
Kim, Hee Jin https://orcid.org/0000-0002-3186-9441
Na, Duk L. https://orcid.org/0000-0002-0098-7592
Jang, Hyemin https://orcid.org/0000-0003-3152-1274
Seo, Sang Won https://orcid.org/0000-0002-8747-0122
,
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Text and Data Mining valid from 2026-01-14

Version of Record valid from 2026-02-10
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Article History

Received: 27 November 2025

Accepted: 30 December 2025

First Online: 14 January 2026

Declarations

:

: The institutional review board of Samsung Medical Center (No. 2021-02-135) approved this study. All participants provided informed consent to participate in the study, and the data were collected in accordance with the Declaration of Helsinki.

: Not applicable.

: The authors declare no competing interests.