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Article History

Received: 16 October 2025

Accepted: 1 January 2026

First Online: 16 January 2026

Declarations

:

: The experiments about hUC-MSCs conformed to the standards set by the Declaration of Helsinki; and the study methodologies were approved by the local ethics committee-stem cell clinical Research Institute, China-Japan Union Hospital, Jilin University. Institutional Ethics approval No. is 2018122502. Date of approval is 2018, Dec., 25th. The donor provided written informed consent to donate the umbilical cord for extraction of hUC-MSCs. The informed consent was signed on 2019, Sep., 17th.All animal experiments comply with the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications No. 8023, revised 1996) and approval from the Institutional Animal Care and Use Committee of Jilin University. The work has been reported in line with the ARRIVE guidelines 2.0. Committee of Experimental Animal Welfare Ethics, College of Life Sciences, Jilin University. Title of the approved project is “The mechanistic study of lncRNA CLIC6 derived from human umbilical cord mesenchymal stem cell exosomes in mediating the miR-31-5p/RAB27A axis for the treatment of Alzheimer's disease”. Appl. No. is YNPZSY2025062, Date of approval is 2025, Aug., 14th.

: Consent for publication is included in the written informed consent obtained from all participants.

: The authors declare no competing interests.