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Intranasal administration of neural stem cell-derived extracellular vesicles prevents cognitive decline in both male and female 3×Tg-AD mice by dampening neuroinflammation and epigenetically regulating amyloid β metabolism

Crossref DOI link: https://doi.org/10.1186/s13195-026-02014-7

Published Online: 2026-04-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Natale, Francesca

Dellaria, Alice

Nifo Sarrapochiello, Ida

Leone, Lucia

Spinelli, Matteo

Rinaudo, Marco

Garofalo, Nicoletta

Grassi, Claudio

Fusco, Salvatore
Funding

Funding for this research was provided by:

Ministero della Salute (Ricerca Corrente)
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Text and Data Mining valid from 2026-04-01

Version of Record valid from 2026-05-20
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Article History

Received: 21 October 2025

Accepted: 11 March 2026

First Online: 1 April 2026

Declarations

:

: All procedures performed on animals were approved by the Ethics Committee of Università Cattolica del Sacro Cuore (authorization no. 949/2023-PR) in accordance with the Italian (Ministry of Health guideline, Legislative Decree No 116/1992) and European Union legislation governing animal research (Directive 2010/63/EU). Consent to Participate and Consent to Publish declarations: not applicable.

: Not applicable.

: The authors declare no competing interests.

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