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Article History

Received: 11 December 2024

Accepted: 14 February 2025

First Online: 15 March 2025

Declarations

:

: This manuscript reports an analysis of data from previously published trials in which patient consent and ethics approval were obtained. This analysis did not involve additional human subject participation.

: H. Henry Li is a speaker for BioCryst, CSL Behring, Pharming, and Takeda, and has received research and consultancy grants from BioCryst, BioMarin, CSL Behring, Ionis, Pharming, Phavaris, and Takeda. Emel Aygören-Pürsün has received grants from CSL Behring and Takeda and consulting fees from CSL Behring, Biocryst, KalVista Pharmaceuticals, and Pharvaris; has received speaker fees from CSL Behring, Biocryst, Centogene, Pharming and Takeda; and has received fees as an advisor for Astria, Biocryst, BioMarin Europe, Centogene, CSL Behring, Intellia, KalVista Pharmaceuticals, Pharming, Pharvaris and Takeda. Markus Magerl has received personal fees/non-financial support from Astria, BioCryst, CSL Behring, Inois, Intellia, KalVista Pharmaceuticals, Octapharma, Pharming, Pharvaris, and Shire Takeda. Timothy Craig has served as a speaker and researcher for Astria, CSL Behring, Intellia, KalVista Pharmaceuticals, and Takeda; a researcher for BioMarin, Ionis, and Pharvaris; speaker for Grifols; a consultant for Astria, BioCryst, CSL Behring, Intellia, KalVista Pharmaceuticals, and Takeda; and is also Director of the ACARE International Hereditary Angioedema Center and a member of the Medical Advisory Board for the United States Hereditary Angioedema Association (HAEA). Michael E. Manning is a speaker for Amgen, AstraZeneca, BioCryst, Blueprint, CSL Behring, Genentech, GSK, KalVista Pharmaceuticals, Pharming, Sanofi/Regeneron, and Takeda; has received research grants from Allakos, Astria, BioCryst, CSL Behring, GSK, KalVista Pharmaceuticals, Merck, Novartis, Pharming, Pharvaris, and Takeda; and has served as a consultant for BioCryst, CSL Behring, Cycle Pharmaceuticals, KalVista Pharmaceuticals., Pharming, and Takeda. Noemi Hummel is an employee of Certara, which is a paid consultant to KalVista Pharmaceuticals. Agnieszka Kopiec is an employee of Certara, which is a paid consultant to KalVista Pharmaceuticals. Shuai Fu is an employee of Certara, which is a paid consultant to KalVista Pharmaceuticals. James Morris is an employee of Cogentia, which is a paid consultant to KalVista Pharmaceuticals. Alice Wang is an employee of KalVista Pharmaceuticals. Paul K. Audhya is an employee of KalVista Pharmaceuticals. Jonathan A. Bernstein has received grants and/or honoraria from BioCryst, BioMarin, CSL Behring, Intellia, Ionis, KalVista Pharmaceuticals, Pharming, Pharvaris, and Takeda/Shire and is the immediate past president of the AAAAI.