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Article History

Received: 19 May 2019

Accepted: 10 September 2019

First Online: 4 December 2019

Ethics approval and consent to participate

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: The authors of this manuscript declare relationships with the following companies outside the submitted work:AC, LEU, DF, MT, PVF, MS, LAM, GS, and AB declare that they have no competing interests.SP has received personal fees and honoraria for lectures from Boehringer Ingelheim, Delphi International Srl, and F. Hoffmann-La Roche Ltd., outside from the submitted work, and he has been also included in a scientific board for Boehringer Ingelheim, outside from the submitted work.SET have received personal fees and honoraria for lectures from Boehringer Ingelheim and F. Hoffmann-La Roche Ltd., outside from the submitted work.CV is part of the F. Hoffmann-La Roche Ltd. Scientific board, and he has received consulting fees and/or speaker fees from AstraZeneca, Boehringer Ingelheim, Chiesi, F. Hoffmann-La Roche Ltd., and Menarini.