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Article History

Received: 2 October 2018

Revised: 14 February 2019

Accepted: 6 March 2019

First Online: 18 March 2019

Ethics approval and consent to participate

: Fetal femur-derived MSCs were obtained following informed, written patient consent. Approval was obtained by the Southampton and South West Hampshire Local Research Ethics Committee (LREC 296100). Adult mesenchymal stem cells, used for generation of iPSCs and iMSCs, were isolated from the bone marrow after written informed consent. The corresponding protocol was approved by the research ethics board of the Charite-Universitätsmedizin, Berlin (IRB approval EA2/126/07). Isolation of mesenchymal stem cells from aged individuals was approved under the Southampton and South West Hampshire Local Research Ethics Committee (LREC 194/99). The Ethics commission of the medical faculty at Heinrich Heine University Düsseldorf also approved this study (Study number: 5013).

: Not applicable.

: The authors declare that they have no competing interest.

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