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AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation

Published Online: 2021-09-25

Published Print: 2021-12

Authors

Sekita, Yoichi

Sugiura, Yuki

Matsumoto, Akari

Kawasaki, Yuki

Akasaka, Kazuya

Konno, Ryo

Shimizu, Momoka

Ito, Toshiaki

Sugiyama, Eiji

Yamazaki, Terushi

Kanai, Eriko

Nakamura, Toshinobu

Suematsu, Makoto

Ishino, Fumitoshi

Kodera, Yoshio

Kohda, Takashi

Kimura, Tohru https://orcid.org/0000-0001-9227-0996
Funding

Funding for this research was provided by:

Japan Society for the Promotion of Science London (JP15K18458)

Japan Society for the Promotion of Science (20K07577, JP24390097)

Takeda Science Foundation

Kitasato University Research Grant for Young Researchers

Nanken-Kyoten Tokyo Medical and Dental University

the MEXT Joint Usage/Research Center Program at the Advanced Medical Research Center, Yokohama City University
License Information

Text and Data Mining valid from 2021-09-25

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Article History

Received: 11 May 2021

Accepted: 31 August 2021

First Online: 25 September 2021

Declarations

:

: This study does not report on or involve the use of human data or tissue. All animal care and experiments were carried out in accordance with Guidelines of Animal Experiments of Kitasato University and were approved by Institutional Animal Care and Use Committee of Kitasato University (Approval number: SAS2004). The study was carried out in compliance with the ARRIVE guidelines ().

: Not applicable.

: The authors declare no competing financial and non-financial interests.

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