Document is current

Article History

Received: 23 August 2021

Accepted: 16 October 2021

First Online: 21 March 2022

Declarations

:

: Cord blood cells were purchased from HemaCare, and healthy donor human peripheral blood mononuclear cells were obtained from the UCLA/CFAR Virology Core Laboratory, without identification information under federal and state regulations. Protocols using these human cells were exempted by the UCLA Institutional Review Board (IRB). SARS-CoV-2, isolate USA-WA1/2020, was obtained from the Biodefense and Emerging Infections (BEI) Resources of the National Institute of Allergy and Infectious Diseases (NIAID). Importantly, all studies involving SARS-CoV-2 infection were conducted within a Biosafety Level 3 facility at UCLA. The mice used in this study were maintained in the animal facilities at UCLA. All animal experiments were approved by the Institutional Animal Care and Use Committee of UCLA.

: Not applicable.

: Y.-R. L. and L.Y. are inventors on patent relating to this study filed by the University of California, Los Angeles (UCLA); the patent has been licensed by Appia Bio. J.Y. is currently an employee of Appia Bio. P.W. and L.Y. are cofounders of Appia Bio, and have consulting, equity, and board relationships with Appia Bio. All other authors declare no competing interests. The declared company did not contribute to or direct any of the research reported in this article.