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Authors
Garcia-Llorens, Guillem
Martínez-Sena, Teresa
Pareja, Eugenia
Tolosa, Laia
Castell, José V.
Bort, Roque https://orcid.org/0000-0002-7285-0536
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Funding
Funding for this research was provided by:
Ministerio de Ciencia e Innovación (SAF2014-51991R)
Conselleria d'Educació, Investigació, Cultura i Esport (PROMETEO/2019/060)
H2020 European Research Council (681002)
Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana (acif/2019/145)
Instituto de Salud Carlos III (fi18/00260)
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Article History
Received: 21 September 2022
Accepted: 28 March 2023
First Online: 18 April 2023
Declarations
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: The punch skin biopsy from a homozygous alphap-1-antitrypsin deficiency with Pi*ZZ genotype patient was freely donated for this study. Prior informed consent in writing was obtained and the study was revised and approved by the institutional ethical committee (title: Nuevas estrategias para generar hepatocitos humanos mediante reprogramación cellular, approved Oct 5th 2015; number 2014-0672). Human liver samples were obtained from three different donors. Informed consent in writing was obtained and reflected in approval by the institutional ethical committee (title: Diferenciación de células somáticas y progenitoras en células de linaje hepático, y su uso con fines diagnósticos y terapéuticos en hepatotoxicidad idiosincrásica por medicamentos, approved Dec 22nd 2021; number 2021-771-1). The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki.
: Not aplicable.
: The authors declare no competing financial interests.
