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Article History

Received: 25 June 2024

Accepted: 2 September 2024

First Online: 11 September 2024

Declarations

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: Human discarded normal cord blood samples (CB) and tracheal aspirates (TA) of preterm infants with gestational age at birth ≤ 27 weeks were collected after obtaining consent from the parents and the study was approved by the Ethics Committee of the Shenzhen Maternity & Child Healthcare Hospital. The title of approved study is “Investigating the molecular mechanisms by which M1 macrophages-derived extracellular vesicles modulate EPCs to impair vascular development in BPD lungs via the miR-663a-JUND axis (M1型巨噬细胞外泌体通过miR-663a-JUND轴调控EPC在BPD肺血管生成障碍中的机制研究)”, and date of approval is May 17th, 2021 (Approval number: SFYLS (2021) 020). All animal experiments were performed in accordance with approved protocols by the Institutional Animal Care and Use Committee (IACUC) of Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Science (CAS) and were reported in line with the ARRIVE guidelines 2.0. (1) Title of the approved project: Investigating the molecular mechanisms by which M1 macrophages-derived extracellular vesicles modulate EPCs to impair vascular development in BPD lungs via the miR-663a-JUND axis (M1型巨噬细胞外泌体通过miR-663a-JUND轴调控EPC在BPD肺血管生成障碍中的机制研究); (2) Name of the institutional approval committee: IACUC of SIAT of the CAS; (3) Approval number: SIAT-IACUC-190610-CXY-A0756; (4) Date of approval: June 14th, 2019.

: All authors confirm their consent for publication.

: All the experiments in this work have been reported in line with the ARRIVE guidelines 2.0.

: The authors declare that they have no competing interests.