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Article History

Received: 6 May 2024

Accepted: 11 December 2024

First Online: 20 December 2024

Declarations

:

: The iPSCs used in our research was obtained from CORIELL Institute (GM25256, USA), which appropriate consent was obtained at the time of biospecimen collection. Clinical-grade UCMSCs was obtained from China Medical Management Consulting (Beijing) LTD. CO. Human umbilical cords were provided by women who gave birth at Yantai Laiyang Central Hospital (Yantai, China). The collection of umbilical cords and the development of mesenchymal stem cells were reviewed and approved by Laiyang Central Hospital of Yantai City on November 14, 2023, with approval number of 2023-002-001. Title of the approved project was “Umbilical cord collection and development of mesenchymal stem cells”. Written informed consent was obtained from the donors participating in the study. All procedures that involved human samples were approved by the ethics committee of Academy of Military Medical Sciences (AF/SC-08/02.425). Title of the approved project was “Experimental study on intervention effect of mesenchymal stem cells derived small extracellular vesicles on radiation-induced cardiac organoid injury”. All procedures that involved animals were approved by the Institutional Animal Care and Use Committee of the Laboratory Animal Center of Academy of Military Medical Sciences (IACUC-DWZX-2023-532). Title of the approved project was “Study on protective effect of stem cells derived small extracellular vesicles on radiation-induced heart damage in mice”.

: Not applicable.

: The authors declare no competing financial interest.