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Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis

Crossref DOI link: https://doi.org/10.1186/s13287-025-04231-7

Published Online: 2025-03-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Ying

Cui, Yang

Liu, Xiaoyu

Liang, Shengxian

Zhong, Li

Guo, Rui https://orcid.org/0000-0001-7417-7018
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (32171181)

Natural Science Foundation of Hebei Province (H2023201901)
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Text and Data Mining valid from 2025-03-05

Version of Record valid from 2025-03-05
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Article History

Received: 21 October 2024

Accepted: 14 February 2025

First Online: 5 March 2025

Declarations

:

: H9-hESCs were generously obtained from the Research Center for Eco-Environmental Sciences under the Chinese Academy of Sciences. The protocol was approved by the Hebei University Animal Welfare and Ethical Committee (Project: Role of Cathepsin K in the Development of Diabetic Atherosclerosis by regulating SERCA2-SUMOylation. No. IACUC-2021XG032, approved on Mar. 11, 2021).

: The authors declare no competing financial interests.

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