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Authors
Zhang, Di
Chen, Taige
Liang, Qi
Feng, Xuebing
Jiang, Jiaxuan
Chen, Zeying
Tang, Yun
Chu, Yiran
Wang, Bin
Hu, Kai
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Clinical Trials BETA
Clinical trials referenced in this document:
nct05784519 at ClinicalTrials.govDocuments that mention this clinical trial
A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry eye disease
https://doi.org/10.1186/s13287-025-04292-8
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Funding
Funding for this research was provided by:
Nanjing Drum Tower Hospital (2022-LCYJ-MS-36)
National Natural Science Foundation of China (81870695)
Natural Science Foundation of Jiangsu Province (BK20201114)
Nanjing Municipal Health Bureau (ZKX20022)
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Article History
Received: 16 October 2024
Accepted: 24 March 2025
First Online: 23 April 2025
Declarations
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: The study was approved by the local ethics committee, all patients provided written informed consent before the procedure. The Ethical approval details are as follows: Title: Study on the curative effect of mesenchymal stem cell eye drops on dry eye disease. The institutional approval committee: Medical Ethics Committee of Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School. Approval number: SC202200102. Date of approval: 01 June, 2022. The human umbilical cord-derived MSCs utilized in this study were procured from the Clinical Stem Cell Center at Nanjing Drum Tower Hospital. As previously documented [], ethical clearance was obtained from the Medical Ethics Committees of Nanjing Drum Tower Hospital for the project titled "Utilization of Clinical Patient Samples (Tissue/Blood/Body Fluids) and Aborted Fetal Tissue to Extract Stem Cells for Basic and Clinical Research in Regenerative Medicine and Treatment of Clinical Diseases" (Approval No. 2017–161-08; Approval Date: November 30, 2017). Informed consent forms were signed by all donors prior to sample collection, ensuring adherence to ethical guidelines for research involving human subjects.
: The patients gave consent for the publication of the data.
: The authors have declared that no conflict of interest exists.
: The authors declare that they have not use AI-generated work in this manuscript.
