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Authors
Ho, Chao-Ting
Kao, Ying-Chi
Shyu, Yueh-Ming
Wang, I-Ching
Liu, Qiao-Xuan
Liu, Shao-Wen
Huang, Shih-Chen
Chiu, Han
Hsu, Li-Wen
Hsu, Tzu-Sheng https://orcid.org/0000-0002-8597-6939
Hsieh, Wan-Chen https://orcid.org/0000-0003-1028-4732
Huang, Chieh-Cheng https://orcid.org/0000-0003-1773-8450
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Funding
Funding for this research was provided by:
National Tsing Hua University
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Article History
Received: 10 December 2024
Accepted: 31 March 2025
First Online: 12 April 2025
Declarations
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: The human MSCs used in this study were obtained from the Food Industry Research and Development Institute (BCRC #60605; Hsinchu, Taiwan)[]. Their collection was ethically approved by the Institutional Review Board of Taipei Medical University, Taiwan, with informed consent obtained from all donors []. The animal study was approved by the Institutional Animal Care and Utilization Committee of National Tsing Hua University (Title of the approved project: Study on the mechanism and application of 3D MSC spheroids with macromolecular crowding-mediated enhancement of Toll-like receptor 3 activation for regulating post-insult neuroinflammation; Approval No. 111056; Date of approval: 11/04/2023). The study complies with the 2018 Guidelines for the Care and Use of Laboratory Animals issued by the Council of Agriculture, Executive Yuan, Taiwan, and adheres to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guideline 2.0.
: The authors declare no competing interests.
