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Article History

Received: 22 February 2025

Accepted: 4 April 2025

First Online: 17 April 2025

Declarations

:

: The hTERT-AT-MSCs cell line used in this study was obtained from ATCC under a Material Transfer Agreement (MTA) with the University of the Basque Country (UPV/EHU). ATCC ensures that all human-derived materials it distributes comply with 45 CFR 46 and relevant ethical regulations. As part of its policy, ATCC requires depositors to confirm that all human tissue samples used to establish cell lines were collected under protocols approved by an Institutional Review Board (IRB), with prior informed consent from donors or their legally authorized representatives, and with appropriate confidentiality safeguards in place. Additionally, the Material Transfer Agreement (MTA) between ATCC and our institution explicitly states that the materials provided have been collected in compliance with all applicable ethical regulations, including donor consent and confidentiality protections. Further documentation is available in the ATCC Donor Policy Letter (2021) and the MTA Agreement (2020, 2024).Buffy coats from healthy donors were obtained from the Basque Biobank, originally isolated from the blood of healthy donors at the Basque Transfusion Centre. The transfer and use of samples was performed in accordance with the requirements of Law 14/2007, of 3 July, on Biomedical Research, and Royal Decree 1716/2011, of 18 November, which establishes the basic requirements for biobanks and handling of human biological samples for biomedical research purposes. The Basque Biobank operates with approval from the Clinical Research Ethics Committee of the Basque Country (CEIm CES-BIOEF, approval number 2023-06, dated 28/02/2023). The research protocol entitled “Use of peripheral blood mononuclear cells (PBMC) for the evaluation of delivery systems of immunomodulatory and/or immunoenhancing therapies” was approved by the Ethics Committee for Research Involving Human Subjects (CEISH) at the University of the Basque Country (UPV/EHU), approval number M10_2022_131MR1, dated 1/06/2022. Volunteers provided written informed consent for the use of their blood samples in research. Additionally, the use and handling of these cells were approved by the Research Ethics Committee for Biological Agents and Genetically Modified Organisms (CEIAB, UPV/EHU), approval number M30_2022_132MR1, dated 21/03/2023.

: Not applicable.

: The authors declare that they have no competing interests.