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Pooling umbilical cord-mesenchymal stromal cells derived from selected multiple donors reduces donor-dependent variability and improves their immunomodulatory properties

Crossref DOI link: https://doi.org/10.1186/s13287-025-04361-y

Published Online: 2025-05-20

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Mebarki, Miryam https://orcid.org/0000-0003-3413-0463
Moine-Picard, Coralie

Enjaume-Rauch, Romain

Laurent-Puig, Antoine

Suissa, Annaelle

Feyants, Valentine

Larghero, Jérôme

Cras, Audrey
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Text and Data Mining valid from 2025-05-20

Version of Record valid from 2025-05-20
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Article History

Received: 13 November 2024

Accepted: 23 April 2025

First Online: 20 May 2025

Declarations

:

: For UC samples: (1) Title of the approved project: « autorisation d’activité de conservation et de préparation d’éléments du corps humain en vue de leur cession pour un usage scientifique». (2) Name of the institutional approval committee or unit: Direction générale de la recherche et de l’innovation, Ministère de l’enseignement supérieur et de la recherché. (3) Approval number: AC-2022-5325. (4) Date of approval: 19 December 2022. All mothers have provided written informed consent for the use of samples. For blood samples (PBMC): (1) Title of the approved project: « convention cadre de cession de produits issus du sang ou de ses composants à but non thérapeutique». (2) Name of the institutional approval committee or unit: Etablissement Français du Sang/Inserm. (3) Approval number: CCPSL 2024-2027-001. (4) Date of approval: 2 January 2024. All healthy donors have provided written informed consent for the use of samples.

: Not applicable.

: The authors declare that they have no competing interests.

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