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Authors
Zhang, Haifeng
Yang, Yanmeng
Wu, Yingnan
Denslin, Vinitha
Koh, Yi Wei Justin
Liu, Ling
Zhuo, Wenhai
Lam, Wing Moon Raymond
Yu, Yinxian
Hui, James Hoi Po
Yang, Zheng https://orcid.org/0000-0003-4275-0590
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Funding
Funding for this research was provided by:
National Medical Research Council of Singapore (MOH-000371-00)
Natural Science Foundation of Shanghai Municipality (23ZR1451700)
Medical-Engineering Cross Project of Shanghai Jiao Tong University (YG2022QN076)
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Article History
Received: 26 December 2024
Accepted: 21 May 2025
First Online: 7 June 2025
Declarations
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: All animal procedures were performed according to the guidelines of the Institutional Animal Care and Use Committee at National University of Singapore. Project Title: Cartilage tissue engineering with mesenchymal stem cells and extracellular vesicles from manipulated MSCs. Protocol number: R2020-0258. Approval date: 21/05/2020.The access to human OA cartilage tissues was according to the guidelines of National Healthcare Group Domain Specific Review Board (NHG DSRB Ref: 2024–3392). Study title: Zonal chondrocytes for improved strategy of autologous chondrocyte implantation in cartilage repair. Approval date: 09/10/2024.The original source for hMSC (Lonza; as stated in their Certificate of Analysis) and 293T/17 (ATCC, file:///C:/Users/dosyz/Downloads/CRL-11268%20Product%20Sheet%20-%20293T_17%20[HEK%20293T_17]%20 []. pdf) have confirmed that there was initial approval for collection of these human cell, and that the donors had signed informed consent. The information can be found on company website.
: Informed consent to participate in research study has been obtained.
: The authors report no conflict of interest.
