Marcianti, Angela https://orcid.org/0000-0001-6393-196X
Spampinato, Eleonora https://orcid.org/0009-0009-3399-5087
Nava, Sara https://orcid.org/0000-0001-9912-8255
Stella, Giulia Maria https://orcid.org/0000-0002-9130-2607
Perego, Paola https://orcid.org/0000-0003-2806-7269
Pogliani, Simona https://orcid.org/0000-0002-5714-6225
Frigerio, Simona https://orcid.org/0000-0001-7078-075X
Mirra, Luca https://orcid.org/0009-0009-5469-702X
Gagni, Paola https://orcid.org/0000-0002-3652-6173
Moda, Fabio https://orcid.org/0000-0002-2820-9880
Cazzaniga, Federico Angelo https://orcid.org/0000-0003-3744-7124
Beretta, Giovanni Luca https://orcid.org/0000-0002-5961-4109
Maronati, Guido
Paglia, Giuseppe https://orcid.org/0000-0003-4724-6801
Corsico, Angelo Guido https://orcid.org/0000-0002-8716-4694
Traversari, Catia https://orcid.org/0009-0008-8473-8286
Lisini, Daniela https://orcid.org/0000-0002-7436-8401
Funding for this research was provided by:
Ministero della Salute (Ministero della Salute, RRC)
Regione Lombardia (Project-ID 2526393)
Article History
Received: 26 February 2025
Accepted: 9 June 2025
First Online: 15 June 2025
Change Date: 6 September 2025
Change Type: Update
Change Details: The original article has been updated to amend the wording in an affiliation.
Declarations
:
: Samples were collected after signed informed consent of no objection for the use for research of surgical tissues in accordance with the Declaration of Helsinki. The informed consents were obtained prior to tissue collection. The project was approved by ethical committee: Title of the approved project: “human Mesenchymal Stromal Cells (MSCs) loaded with drugs and derived Extracellular Vesicles: production process optimization and drug product characterization”. Name of the institutional approval committee: Institutional Review Board of the IRCCS Neurological Institute C. Besta Foundation. Approval number: 15. Date of approval: March 29, 2023. Human cell lines MSTO-211 H and NCI H2052 were purchased from a commercial vendor, ATCC. The company has confirmed that there was initial ethical approval for the collection of human materials and the derivation of cell lines and that the donors had signed informed consent. See for details: ; .
: The authors declare that they have no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. The authors declare that they have not use AI-generated work in this manuscript.