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Authors
Gu, Yuzhou
Chen, Lu
Chen, Shuying
Wu, Yuhao
Hao, Shengjie
Sheng, Feiyin
Yuan, Jiali
Qin, Zhenwei
Wu, Di
Han, Yu
Yao, Zengying
Chen, Zhijian
Wormstone, I. Michael
Yu, Yibo
Qian, Junbin
Fu, Qiuli
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (82471054)
National Natural Science Foundation of China (82271063)
National Natural Science Foundation of China (82201158)
National Natural Science Foundation of China (8207939)
National Natural Science Foundation of China (81870641)
National Natural Science Foundation of China (81670833)
National Natural Science Foundation of China (81300641)
Key Research and Development Program of Zhejiang Province (2019C03091)
Key Research and Development Program of Zhejiang Province (2020C03035)
Key Research and Development Program of Zhejiang Province (2025C02157)
Fundamental Research Funds of the Central Universities (2019QNA7026)
Central Guidance for Local Scientific and Technological Development Funding Program (2024ZY01057)
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Article History
Received: 19 March 2025
Accepted: 9 June 2025
First Online: 1 July 2025
Declarations
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: Ethical approval for this study was obtained from the Ethics Committee of the Second Affiliated Hospital of Zhejiang University. For the animal experiments, approval was granted for the project titled “Mechanisms of Age-Related Cataracts and Drug Screening” (Approval Number: 2024–0142; Date of approval: August 6, 2024). For the use of human-donated lenses, approval was obtained for the project titled “Study on Stemness Alterations and Differentiation Trajectories of Lens Epithelial Cells in Human-donated Lenses” (Approval Number: 2023–0641; Date of approval: June 23, 2023). The organ donor(s) or their guardian(s)/legally authorized representative(s) provided written informed consent for the use of samples. For ESCs, the original source (WiCell Research Institute, Inc.) has confirmed that there was initial ethical approval for collection of human cells, and that the donors had signed informed consent (). The Material Transfer Agreement has been included in the Supplementary Material . All procedures involving animals and human tissues were conducted in strict compliance with the approved ethical guidelines and regulations.
: Not applicable.
: The authors declare that they have no competing interests.
