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Authors
Ma, Yuzhuo
Han, Xiang
Yan, Ke
Yang, Yiyang
Zhang, Kewei
Wang, Yue
Lv, Xuerong
Wang, Feiyang
Wang, Xiaoqian https://orcid.org/0009-0000-9524-4005
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Funding
Funding for this research was provided by:
National Natural Science Foundation of China (82101018)
Opening Project of State Key Laboratory of Oral Diseases (SKLOD2024OF06)
Jiangsu Province Capability Improvement Project through Science, Technology and Education-Jiangsu Provincial Research Hospital Cultivation Unit (YJXYYJSDW4)
Jiangsu Provincial Medical Innovation Center (CXZX202227)
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Article History
Received: 10 March 2025
Accepted: 10 June 2025
First Online: 20 June 2025
Declarations
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: All experimental procedures involving animals were performed according to the institutional animal care guidelines and ethically approved by the Institutional Animal Care and Use Committe (IACUC) of Nanjing Medical University (IACUC-2411053, Title: Investigating the Regenerative Effect of Mitochondrial Transplantation on Periodontal Defects in Rats; Date of approval: Nov 15, 2024). This work has been reported in line with the ARRIVE guidelines 2.0. There were no ethical conflicts associated with this manuscript. The approval encompassed the isolation and preparation of human periodontal ligament stem cells, the recruitment of patients with acute ischemic stroke, and the collection of their biological samples for research purposes. Written informed consent was obtained from all patients or their legally authorized representatives. All human tissue samples were collected following the Ethical Committee Department, Affiliated Hospital of Stomatology, Nanjing Medical University approval (PJ2022-188-001, Title: Mitochondrial transplantation promotes periodontal bone regeneration by regulating inflammatory microenvironment and metabolic homeostasis; Date of approval: Oct 1, 2022). THP-1 was obtained from Jiangsu Province Key Laboratory of Oral Diseases, and the cells were purchased from Procell (Wuhan, China). All human tissue samples were collected following the Ethical Committee Department, Affiliated Hospital of Stomatology, Nanjing Medical University approval (PJ2022-188-001, Title: Mitochondrial transplantation promotes periodontal bone regeneration by regulating inflammatory microenvironment and metabolic homeostasis; Date of approval: Oct 1, 2022). Written informed consent was obtained from all patients or their legally authorized representatives.
: All authors have read and agreed to the published version of the manuscript.
: The authors declare no competing interests.
