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Article History

Received: 7 March 2025

Accepted: 11 June 2025

First Online: 1 July 2025

Declarations

:

: The work has been reported in line with the ARRIVE guidelines 2.0. Human CRC cell lines HCT116 and SW480 were purchased from Institute of Biochemistry and Cell Biology at the Chinese Academy of Sciences (China National Collection of Authenticated Cell Cultures). This agency confirmed that there was initial ethical approval for the collection of human cells with informed consent signed by donors. All animal experiments in the project entitled “MiR-145 encapsulated hucMSC-derived small extracellular vesicles inhibit colorectal cancer growth and progression” were approved by the Institutional Animal Care and Use Committee of Jiangsu University on March 14, 2024 (approval number: JSDX20240314003). Informed consent was acquired from patients with CRCs, and ethical approval was obtained from Ethics Committees of Affiliated Hospital of Jiangsu University (Title of study: Research on the role and mechanism of miR-145 in human lung and colorectal cancers; Reference number: KY2024K0404; Approval date: April 20, 2024).

: Not applicable.

: The authors declare that they have not use AI-generated work in this manuscript.

: The authors declare no competing interests.