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Article History

Received: 15 May 2025

Accepted: 8 September 2025

First Online: 27 October 2025

Declarations

:

: All animal experiments for this study were in accordance with the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines 2.0. All animal procedures and protocols were performed in accordance with the Guide for the Care and Use of Laboratory Animals published by the U.S. National Institutes of Health (8th Edition, 2011) and approved by the Laboratory Animal Management Committee of Jiangsu Province (approval number: IAC-A2019021-P-01; date of approval: May 6, 2019; title of approved project: “the pharmacodynamics of hiPSC-CMs in a monkey myocardial infarction model”). The patients provided written informed consent to participate in the study and for the use of their samples (PBMCs), and the protocol for using PBMCs was approved by the Ethics Committee of Beijing Hospital (approval number: 2020BJYYEC-237-02; date of approval: Feb 29, 2020; title of approved project: “protocol for the collection of peripheral blood mononuclear cells to establish an iPSC cell bank”).

: Not applicable.

: J.W. is a scientific founder and equity holder in HELP Therapeutics Ltd.