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Authors
Qi, Yi
Kawabori, Masahito https://orcid.org/0000-0002-3574-8380
Nakahara, Yo
Tha, Khin Khin
Ohtsuki, Sumio
Fujimura, Miki
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Funding
Funding for this research was provided by:
Japan Society for the Promotion of Science (23K08557, 23K08535, 23H04937, 24K02195)
Platform Project for Supporting Drug Discovery and Life Science Research (JP24ama121018)
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Article History
Received: 4 April 2025
Accepted: 13 October 2025
First Online: 18 November 2025
Declarations
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: Animal protocols were approved by the Animal Studies Ethics Committee of the Hokkaido University Graduate School of Medicine. Experimental title: basic experiment of stem cell treatment for brain disease. Approval number: 21–0123. Date of approval: 2022/11/14. All experimental procedures were conducted in accordance with the Institutional Guidelines for Animal Experimentation, the Guidelines for Proper Conduct of Animal Experiments issued by the Science Council of Japan, and the ARRIVE guidelines 2.0. All animals were housed in standard polypropylene cages (typically 2–3 rats per cage) under specific pathogen-free (SPF) conditions. The animal facility was maintained at a temperature of 22 ± 2 °C, with relative humidity of 50–60% and a 12-hour light/dark cycle. Rats had ad libitum access to autoclaved food and water. Animals were monitored daily for health and welfare.
: All authors agreed to submit the manuscript, read and approved the final draft and take full responsibility of its content, including the accuracy of the data.
: The authors have no conflict of interest to disclose.
