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Authors
Borba, Pedro B.
Torres, Caio L. M.
da Costa, Maria Vitória M.
Luz, Yasmim
da Silva, Kátia Nunes
da Conceição Pires, Sthefany
Loiola, Erick Correia
Figueiredo, Júlio César Queiroz
de Souza Santos, Luciano
Rocha, Gisele Vieira
Menezes, Juliana P. B.
Costa-Ferro, Zaquer Suzana Munhoz
de Freitas Souza, Bruno Solano
de Oliveira, Camila I.
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Funding
Funding for this research was provided by:
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa do Estado da Bahia
D’Or Institute for Research and Education
INOVA FIOCRUZ
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Article History
Received: 15 August 2025
Accepted: 16 October 2025
First Online: 21 November 2025
Declarations
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: The production and characterization of hUCMSC-EVs from donor tissue was approved by the Brazilian National Committee for Ethics in Research (CONEP, CAAE: 76368823.1.0000.0048). (Title: Study of therapeutic applications of mesenchymal stem cells and their extracellular vesicles, 30/08/2024). All participants provided written informed consent for participation in the study and the use of samples. All animal experimentation was conducted according to the Guidelines for Animal Experimentation established by the Brazilian Council for Animal Experimentation Control (CONCEA). The local Institutional Review Board approved all the procedures involving animals for Animal Care and Experimentation (CEUA)-IGM-FIOCRUZ-013/2022) (Title: Evaluation of the toxicity, migration, and anti-inflammatory effects of extracellular vesicles derived from human umbilical cord mesenchymal cells in vitro and in vivo. 15/12/2024).
: All authors read and approved the final version of the manuscript.
: The authors declare no competing interests.
