Zhang, Jing
Li, Yunqi
Ren, Penghui
Jiang, Mengna
Wu, Ping
Wen, Qingping
Funding for this research was provided by:
the United Foundation for Dalian Institute of Chemical Physics, Chinese Academy of Sciences and the First Hospital of Dalian Medical University (DMU-1&DICP UN202402)
the Liaoning Provincial Key Research and Development Program (2024JH2/102500038)
Article History
Received: 14 August 2025
Accepted: 18 November 2025
First Online: 23 November 2025
Declarations
:
: Animal Ethics declaration: All animal experiments were approved by the Animal Ethics Committee of Dalian Medical University (Title of the approved project: Study on the Efficacy and Safety of Human Umbilical Cord-Derived Mesenchymal Stromal Cells in Treating Bone Cancer Pain in Rats, and the Therapeutic Effects of Combined Use with Fentanyl; Approval number: AEE24228; Data of approval: 19 November 2024). The work has been reported in line with the ARRIVE guidelines 2.0. The hUC-MSCs used in this study were all produced and provided by the Stem Cell Clinical Research Center of the First Affiliated Hospital of Dalian Medical University. The umbilical cord tissue was obtained from healthy pregnant donors. All donors signed written informed consent. The use of human umbilical cord tissue was approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University (Approval number: LCKY2016-59; Data of approval: 16 November 2016). Clinical trial number: not applicable.
: Not applicable.
: The authors declare no competing interests.