Xu, Xuejing
Liu, Linghong
Dong, Na
Xin, Tianqing
Shi, Qing
Li, Dong
Ju, Xiuli
Funding for this research was provided by:
Shandong Provincial Hospital for Maternal and Child Health, Ministry of Health Key Laboratory of Reproductive Regulation Technologies (2023005)
Natural Science Foundation of Shandong Province (ZR2024ZD23)
Natural Science Foundation of Shandong Province (ZR2023MH079)
Ji'Nan Science and Technology Bureau (JNKCJN202201)
Article History
Received: 21 May 2025
Accepted: 2 December 2025
First Online: 12 December 2025
Declarations
:
: All animal experiments were approved by the Ethics Committee on Scientific Research of Qilu Hospital of Shandong University (The approved title is Umbilical Cord Mesenchymal Stem Cell Therapy Attenuates Hyperoxia-Induced Multisystem Organ Injury in Neonatal Rats (Approval No. DWLL-2021-035; Date of Approval: March 25, 2021). The hUC-MSCs used in this study were provided for research purposes by Shandong Provincial Umbilical Cord Blood Hematopoietic Stem Cell Bank. The supplier confirmed that original umbilical cord tissue collection was conducted following the protocol, “Umbilical Cord Mesenchymal Stem Cell Therapy in Preterm Infants with Bronchopulmonary Dysplasia: A Prospective Randomized Controlled Trial” approved by the Ethics Committee on Scientific Research of Qilu Hospital of Shandong University (Approval No. KYLL-202008-111; Date of Approval: August 31, 2020); in addition, they confirmed that informed consent was obtained from all donors prior to tissue collection. As this study was conducted on pre-collected, anonymized cells, and did not involve direct human participation, no additional ethics approval was required for their use.
: Not applicable.
: The authors declare no competing interests.