Document is current
Any future updates will be listed below
-
Authors
Lin, Chuanmiao
Wei, Junbin
Zhao, Tingting
Chen, Lingling
Rong, Shuxuan
Zhan, Junkun
Lai, Wenjia
Wang, Yan
Xie, Yunyi
Chen, Huan
-
Funding
Funding for this research was provided by:
Open Funding of Guangdong Provincial Key Laboratory of Stomatology (KF2023120103)
Open Funding of Guangdong Provincial Key Laboratory of Stomatology (KF2023120103)
The National Natural Science Foundation of China (82270978, 82071120)
The National Natural Science Foundation of China (82401139)
China Postdoctoral Science Foundation (2024M763823)
Guangdong Basic and Applied Basic Research Foundation (2025A1515011738)
- License Information
-
More Information
Article History
Received: 2 August 2025
Accepted: 2 January 2026
First Online: 16 January 2026
Declarations
:
: The animal experiments were conducted under the approval of Institutional Animal Care and Use Committee, Sun Yat-Sen University (Title of the approved project: Overexpression of Klotho to alleviate bone loss from periodontitis in mice; Approval No. SYSU-IACUC-2024-001177; Date of approval: 24 March 2024). All animal procedures were conducted in accordance with the ARRIVE guidelines and the relevant institutional regulations. The original source tissue of the human cells used in this study (hPDLSCs) has obtained approval from the Medical Ethics Committee of Hospital of Stomatology, Sun Yat-sen University (Title of the approved project: Biological characteristics of periodontal ligament stem cells; Approval No. KQEC-2022-116-01; Date of approval: 26 October 2022). All donors provided written informed consent prior to tissue collection.
: Graphical abstract and Fig. 6A was created using BioRender (license obtained under the BioRender Academic Publication License) and is included with permission for openaccess publication under CC-BY 4.0. Citation (QD28QR343G, HY28QR7G1M).
: The authors declare no competing interests.
