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Authors
Wu, Huofeng
Zai, Shuangjia
You, Xuan
Liu, Chen
Li, Zhaoyu
Li, Zhengguang
Mei, Yuhui
Hua, Benkui
Tao, Yuping
Wu, Yiming
Zhang, Liang
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Funding
Funding for this research was provided by:
Postgraduate Research and Practice Innovation Program of Jiangsu Province (SJCX24_2340)
National Natural Science Foundation of China (82172462)
the Sixth "333 Project" Outstanding Young Talent Scientific Research Project of Jiangsu Province (11)
Key Projects of Social Development of Yangzhou City (YZ2021083/YZ2022091)
Technology Project of Northern Jiangsu People's Hospital (FCJS202504)
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Article History
Received: 17 September 2025
Accepted: 31 March 2026
First Online: 16 April 2026
Declarations
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: The research titled “From Collapse to Comeback: Luteolin Rejuvenates Nucleus Pulposus Progenitor Cells via SIRT1/ATF5–UPRmt to Reverse Intervertebral Disc Degeneration Cascade” was granted ethical clearance by the Yangzhou University Animal Ethics Committee under the project entitled “Construction of a rat intervertebral disc degeneration model and experimental study of related pharmacological interventions” (Approval No. 202403237, approved on March 15, 2024). All animal experiments were conducted and reported in accordance with the ARRIVE guidelines 2.0. All human participants provided written informed consent. The use of human NP tissue specimens was approved by the Ethics Committee of Northern Jiangsu People’s Hospital Affiliated to Yangzhou University under the project entitled “Clinical collection and mechanistic study of human intervertebral disc tissues in intervertebral disc degeneration” (Approval No. 2021ky050, approved on March 2, 2021).
: Our manuscript does not contain any individual person’s data in any form (including any individual details, images or videos).
: Informed consent was obtained from all individual participants included in the study.
: The authors declare no competing interests.
