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Authors
Rivera-Herrera, Ana Lucia
Rouleau, Michèle
Singbo, Mahukpe Narcisse Ulrich
Cuppens, Tania
Prunier, Julien
Droit, Arnaud
Simonyan, David
Guillemette, Chantal
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Funding
Funding for this research was provided by:
Canadian Institutes of Health Research (FRN-167269)
Canada Foundation for Innovation (#34272)
Canada Research Chairs (CRC-2020-000067)
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Article History
Received: 20 January 2025
Accepted: 29 March 2025
First Online: 22 April 2025
Declarations
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: This study was approved by the local ethics committee (CHU de Québec – UL #2012 − 362). All participants provided written informed consent upon enrollment into the CLSA.
: Not applicable.
: The authors declare no competing interests.
: The opinions expressed in this manuscript are those of the authors and do not reflect the views of the Canadian Longitudinal Study on Aging.
: File name: Additional file 1File format. Pdf.Title of data: Supplementary Figures of Sexual Dimorphism in Metabolomic and Phenotypic Spectra of UGT deficiency: Findings from the Canadian Longitudinal Study on Aging.Description of data:
: Metabolites quantified in this study and number of metabolites in each super-pathway that were available for analysis.
: Gene expression by sex for (A) UGT2B17 and (B) UGT2B28 in human tissues.
: Number of significantly altered metabolites in each UGT KO group relative to the gene-proficient reference group (P < 0.05) by subpathway.
: Relative abundance of significantly dysregulated metabolites in each KO group.
: Associations between significantly altered metabolites in UGT2B17 KO and diseases.
: Associations between significantly altered metabolites in UGT2B17 KO females, UGT2B28 KO males, and diseases.
: File format. Excel.xlsx.Title of data: Supplementary tables of Sexual Dimorphism in Metabolomic and Phenotypic Spectra of UGT deficiency: Findings from the Canadian Longitudinal Study on Aging.Description of data:
: Detail of the chronic diseases / categories of chronic diseases used in this study.
: Fold change of the plasma metabolites measured in KO and reference groups.
: Significant changes in plasma metabolites for postmenopausal women.
: Characteristics of the study groups.
: Top 5 most changed metabolites in UGT2B17 KO, UGT2B28 KO and Double KO for overall and sex-based analyses.
: Top 5 most changed metabolites including unknown and partially characterized metabolites in UGT2B17 KO, UGT2B28 KO and Double KO for overall and sex-based analyses.
