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Authors
Zhu, Lin
Xie, Xianyan
Wang, Huiguo
Chen, Zekai
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Funding
Funding for this research was provided by:
the New Type of Regular Higher Education Institutions Think Tanks in Guangdong Province (2024TSZK017)
The National Social Science Fund of China (23ATY007)
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Article History
Received: 20 December 2025
Accepted: 23 March 2026
First Online: 1 April 2026
Declarations
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: The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee (EC) of Guangzhou Sport University (protocol code 2018LCLL-008,approved date: 2018-06-25).
: Informed consent was obtained from all subjects involved in the study.Written informed consent was obtained from the parents of the patients.
: The authors declare no competing interests.
: The cohort and intervention protocol described in the present study have been previously reported in related publications focusing on different research objectives, including overall metabolomic changes following the intervention, insulin resistance phenotypes, proteomic remodeling, and inter-individual variability in weight loss response. The current manuscript addresses a distinct scientific question, specifically sex-differential metabolic responsiveness to short-term exercise intervention, employing linear mixed-effects models and predictive metabolomic modeling approaches that were not applied in the previous studies.There is no duplication of primary results, statistical models, or interpretations between the present manuscript and prior publications.
