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Article History

Received: 17 June 2018

Accepted: 14 October 2018

First Online: 27 October 2018

Ethics approval and consent to participate

: Care of the animals was conducted in accordance with the guidelines, <i>Guide for the Care and Use of Laboratory Animals</i> (United States Department of Health and Human Services, No 86–23) and <i>The Animal Welfare Act</i> (9 CFR Part 3; USDA No. 34-R-0025). The studies were performed at PsychoGenics, Inc., an organization accredited by the Association for Assessment and Accreditation of Laboratory Animal Care and Agada Biosciences, an organization accredited by the Canadian Council on Animal Care. The studies were approved by the Institutional Animal Care and Use Committees (Shire and PsychoGenics) and Dalhousie University Animal Committee (for Agada Biosciences).

: Not applicable.

: AI, NL, YH, CS, KP, RCrooker, DL, NK, BP, AR, AN, JP, HR, KD, and DE are employees of Shire. QD, JD, and RComeau were employees of Shire when the work was performed. All authors may potentially own stock and/or hold stock options in the company.

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