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Corynebacterium pseudotuberculosis phospholipase D targets mitochondrial sphingomyelin and induces NLRP3-GSDMD axis-mediated pyroptosis in macrophages to promote infection

Crossref DOI link: https://doi.org/10.1186/s13567-025-01640-7

Published Online: 2025-10-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Li, Xincan

Lv, Hong

Wu, Chanyu

Li, Hexian

Yi, Wenyi

Niu, Xiaoxin

Peng, Qiuyue

Meng, Chi

Yuan, Yongfeng

Tian, Shangquan

Wang, Zhiying

Fang, Rendong

Zhou, Zuoyong https://orcid.org/0000-0002-5098-1367
Funding

Funding for this research was provided by:

National Key Research and Development Program of China (2021YFD1800800)

Natural Science Foundation of Chongqing (CSTC2021JCYJ-MSXMX0884)

Natural Science Foundation of Chongqing (CSTB2024NSCQ-MSX1262)

Fundamental Research Funds for the Central Universities (XDJK2018C054)

Fundamental Research Funds for the Central Universities (XDJK2020B016)
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Text and Data Mining valid from 2025-10-16

Version of Record valid from 2025-10-16
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Article History

Received: 7 April 2025

Accepted: 19 August 2025

First Online: 16 October 2025

Declarations

:

: The use of animals in this study was approved by the Laboratory Animal Ethics Committee of Southwest University (Permit Number: IACUC-20230410-03).

: The authors declare that they have no competing interests.

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