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Article History

Received: 9 July 2021

Accepted: 2 December 2021

First Online: 8 December 2021

Declarations

:

: All of the animal procedures were approved by the University of Toronto Animal Care Committee (Animal Use Protocol# 20012653) and the Hospital for Sick Children (Animal Use Protocol #100005778). All experimental procedures were performed in accordance with the Canadian Council on Animal Care (CCAC) and University of Toronto and Hospital for Sick Children regulations.

: We, the authors, consent that the text and any pictures or videos published in the article will be freely available on the internet and may be seen by the general public. The pictures, videos and text may also appear on other websites or in print, may be translated into other languages or used for commercial purposes.

: As a potential conflict of interest, a US provisional patent has been filed by the University of Toronto and Hospital for Sick Children, and Jun Liu, Jim Hu, James Rini and Zhijie Li are the inventors.