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Article History

Received: 9 February 2021

Accepted: 12 October 2021

First Online: 24 October 2021

Declarations

:

: The HYPERION trial protocol was approved by the appropriate ethics committees (<i>Comité d’éthique de la Société de Réanimation de Langue Française</i>, #11-335; and <i>Comité de Protection des Personnes Ouest 2</i>, #2012/08) and French data protection authorities (<i>Commission Nationale de l’Informatique et des Libertés</i>, #DR2013-600; and <i>Comité Consultatif sur le Traitement de l’Information en Matière de Recherche dans le Domaine de la Santé</i>, #13-455). The AWARE trial was approved by the institutional review board of Clermont-Ferrand, France, and by the Ethics Committee of the French Intensive Care Society (SRLF, Société de Réanimation de Langue Française). Informed consent or deferred consent was obtained from each patient or his/her legal surrogate. The INSEE anonymized database was freely available upon request (ExternalRef removed).

: Dr Lascarrou has received reimbursement for travel expenses and lecture fees from Zoll (Voisin Le Bretonneux, France) and BD (Le Pont de Claix, France). Pr Cariou has received lecture fees from BD (Le Pont de Claix, France). None of the other authors has any conflict of interest to declare.