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Authors
Landoni, Giovanni
Chowdary, Pratima
Meziani, Ferhat
Creteur, Jacques
De Schryver, Nicolas
Motsch, Johann
Henrichmoeller, Ingrid
Pagès, Alain
Peter, Nuala
Danays, Thierry
Weigand, Markus A.
,
Zoufaly, Alexander
Seitz, Tamara
Pawelka, Erich
Neuhold, Stephanie
Höpler, Wolfgang
Rumpf, Benedikt
Totschnig, David
Likar, Rudolf
Koestenverger, Markus
Neuwersch-Sommeregger, Stefan
Creteur, Jacques
Ego, Amedee
Moreau, Anthony
Grimaldi, David
Annoni, Filippo
Gorham, Julie
Halenarova, Katarina
Pletschette, Zoe
Brasseur, Alexandre
Taccone, Fabio
Nobile, Leda
Lheureux, Olivier
Snacken, Morgane
Dehout, Charles
De Schryver, Nicolas
Vinetti, Marco
Serck, Nicolas
Dugernier, Thierry
Layios, Nathalie
Parzibut, Gilles
Boldo, Rodrigo
dos Santos, Vanessa Santos
Nunes, Cristine Erdmann
Diehl, Jean-Luc
Aissaoui, N
Augy, J
Guerot, E
Hauw-Berlemont, C
Hermann, B
Peron, N
Santi, F
Langlais, J
Troger, A
Chekhrit, K
Poissy, Julien
Caplan, M
El Kalioubie, A
Favory, R
Gaudet, A
Goutay, J
Preau, S
Rouze, A
Mariller, Laure
Mira, Jean-Paul
Hamou, Z Ait
Ghanem, S Ben
Bertrix, M
Charpentier, J
Creutin, T
Jozwiak, M
Laghlam, D
Peju, E
Pene, F
Vigneron, C
Meziani, Ferhat
Demisselle, J
Helms, J
Jandeaux, L
Kummerlen, C
Merdji, H
Monnier, A
Rahmani, H
Studer, A
Cunat, S
Hakkari, Ouafa
Monnet, Xavier
Adda, I
Anguel, N
Ayed, S
Fosse, Q
Guerin, L
Osman, D
Pavot, A
Pham, T
Carpentier, C
Denormandie, P
Lai, C
Fourreau, Alain
Monchi, Mehran
Ellrodt, O
Jochmans, S
Mazerand, S
Rolin, N
Serbource-Goguel, J
Soulier, P
Sy, O
Benane, Nourdine
Mourvillier, Bruno
Cousson, J
Goury, A
Passouant, O
Thery, G
Castex, Cédric
Lascarrou, Jean-Baptiste
Roquilly, A
Canet, E
Garret, C
Lemarie, J
Martin, M
Reignier, J
Seguin, A
Zambon, O
Lamouche Wilquin, P
Agbakou, M
Decamps, P
Desmedt, L
Blonz, G
Hourmant, Y
Grillot, N
Rouhani, A
Bouras, M
Mahe, P.-J.
Latte, D. Demeure Dit
Bourdiol, A
Benkalfate, N
Carpentier, M
Guillotin, F
Benguerfi, S
Motsch, Johann
Zimmermann, Johannes
Al Halabi, Karam
Altvater, Marc
Decker, Sebastian
Fiedler, Mascha
Knebel, Phillip
Maichle, Barbara
Weigand, Markus
Welte, Tobias
Drick, Nora
Pink, Isabelle
Schmidt, Julius Johannes
Bercker, Sven
Simon, Philipp
Fichtner, Falk
Hempel, Gunther
Kliem, Peter
Kluba, Karsten
Laudi, Sven
Müller, Sarah
Oesemann, Rene
Roedel, Michael
Schering, Stefan
Schulz, Sebastian
Seeber, Christian
Ullmann, Hannah
Ziganshyna, Svitlana
Jahn, Nora
Boerge, Bastian
Keller, Maren
Irlbeck, Michael
Frank, Sandra
Hoffmann, Ursula
Huseynov, Aydin
Britsch, Simone
Ishar-Singh, Gill
Jabbour, Claude
Stieglitz, Sven
Guelker, Jan-Erik
Cecconi, Maurizio
Greco, Massimiliano
Monti, Giacomo
Azzolini, Maria Luisa
Righetti, Beatrice
Diaz, Francisco Marquez
Girón, Sofía Elizabeth
de La Cruz, Alejandra Aviles
Ibarra, Ana Elena Ramírez
Romo, Paola Hernández
García, Marián Serna
Castillo, Andrés García
Spronk, Peter
Kuindersma, Marnix
Blans, Michiel
Leeuwen, Henk
Peters, Marco
Rengers, Els
Hoiting, Oscar
Filimonov, Viktor Borisovich
Peshenniokva, Maria
Kravchenko, Olga
Karev, Yuri
Filimonova, Anastasiia
Avdeev, Sergey Nikolaevich
Chikina, Svetlana
Gneusheva, Tatiana
Merzhoeva, Zamira
Nekludova, Galina
Protsenko, Denis Nikolaevich
Tyurin, Igor
Matyushkov, Nikita
Lisun, Tatiana Valerievna V.
Boyarkov, Aleksandr
Bobkova, Svetlana
Klinov, Alexey
Schukarev, Dmitry
Smolin, Nikolay
Ferrer, Ricard
Nuvials, Xavier
Contreras, Sofia
Cortés, Alejandro
Lora, Mariel Rojas
Sierra, Rafael
Alarbe, Samer
Fernandez, Ana
Contreras, Mario
Freire, María Dolores
Revuelto, Jaume
Celaya, Mikel
Marín, Judith
Parrilla, Francisco
Perez, Purificación
Muñoz, Rosana
Diaz, Emilio
Mora, Cristina
de Haro, Candelaria
Moglia, Edgard
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Clinical Trials BETA
Clinical trials referenced in this document:
nct04640194 at ClinicalTrials.govDocuments that mention this clinical trial
Alteplase in COVID-19 severe hypoxemic respiratory failure: the TRISTARDS multicenter randomized trial
https://doi.org/10.1186/s13613-024-01386-z
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Funding
Funding for this research was provided by:
Boehringer Ingelheim
Universitätsklinikum Heidelberg
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Article History
Received: 9 April 2024
Accepted: 21 September 2024
First Online: 10 November 2024
Declarations
:
: The trial was conducted per the clinical trial protocol and in accordance with the principles of the Declaration of Helsinki, International Council on Harmonization Good Clinical Practice (ICH GCP) guidelines, and Boehringer Ingelheim standard operating procedures. Patients or their legal representative signed and dated an informed consent form per local regulatory and legal requirements.Prior to start of the trial, the clinical trial protocol (0135–0347, protocol version 2 dated 22 Oct 2020), the patient information leaflet, informed consent form and other locally required documents were reviewed and approved by the Independent Ethics Committees and/or Institutional Review Boards (IECs/IRBs) of the participating centers.
: Not applicable.
: Giovanni Landoni reports personal fees from Boehringer Ingelheim for participation on an advisory board. Ferhat Meziani and Jacques Creteur have nothing to declare. Nicolas De Schryver reports personal fees from Trium CC for his role on a data safety monitoring board. Johann Motsch reports payment to his institution by Boehringer Ingelheim for the funding and provision of materials for the TRISTARDS study. Pratima Chowdary declares participation on an advisory board for Boehringer Ingelheim, and receipt of a free drug for a tPA trial in COVID-19 to the Royal Free London NHS Foundation Trust. Ingrid Henrichmoeller, Alain Pagès and Nuala Peters are full-time employees of Boehringer Ingelheim International GmbH. Thierry Danays reports consulting fees from Boehringer Ingelheim paid to TDC. Markus A. Weigand reports grants or contracts from Köhler Chemie, DFG and BMBF, consulting fees from B. Braun, Gilead, Mundipharma and Boehringer Ingelheim, and payment or honoraria for lectures, presentations, speaker bureaus, manuscript writing or educational events from MSD, Gilead, Shionogi, Pfizer and Beckman Coulter. Dr Weigand is also a patent owner (EP17185036.5 and EP17198330.7), has participated on a data safety monitoring board or advisory board for MSD, Gilead, Shionogi, Biotest, Pfizer, Eumedica, SOBI and Beckman Coulter, is the vice-head of the German Sepsis Society and the scientific advisory council PEG, and is cofounder of Delta Theragnostics.
