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Neurotrophic factor-α1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer’s disease mice

Crossref DOI link: https://doi.org/10.1186/s40035-025-00520-6

Published Online: 2025-11-26

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Xiao, Lan

Sharma, Pranav https://orcid.org/0000-0003-4064-4049
Yang, Xuyu

Abebe, Daniel

Loh, Y. Peng https://orcid.org/0000-0002-5404-723X
Funding

Funding for this research was provided by:

National Institute of Child Health and Human Development (Intramural research grant)

National Institutes of Health
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Text and Data Mining valid from 2025-11-26

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Article History

Received: 2 July 2025

Accepted: 25 October 2025

First Online: 26 November 2025

Declarations

:

: All animal study protocols were approved by the Animal Care and Use Committee of NICHD, NIH and complied with ethical regulations.

: Not applicable.

: The authors declare no conflict of interest.

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