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Article History

Received: 4 November 2021

Accepted: 21 February 2022

First Online: 25 March 2022

Declarations

:

: Both TRANSCEND and JULIET were conducted in accordance with the Declaration of Helsinki, International Conference on Harmonization Good Clinical Practice guidelines, institutional review boards at participating institutions approved the study protocols and amendments, and all patients provided written informed consent.

: All the authors have signed the form of consent to publication.

: Guillaume Cartron has received consultancy fees from Celgene, a Bristol-Myers Squibb Company, and F. Hoffmann-La Roche; and honoraria from AbbVie, Celgene, a Bristol-Myers Squibb Company, F. Hoffmann-La Roche, Gilead Sciences, Janssen, and Sanofi. Christopher P. Fox has received honoraria from AbbVie, Adienne, AstraZeneca, Atara Biotherapeutics, Celgene, a Bristol-Myers Squibb Company, Genmab, Gilead Sciences, Incyte, Roche, Sunesis Pharmaceuticals, and Takeda; and grants for research from AbbVie, Adienne, Gilead Sciences, Roche, and Takeda. Fei Fei Liu, Ana Kostic, and Daniel Li are employees of Bristol Myers Squibb and hold stock in Bristol Myers Squibb. Jens Hasskarl was an employee of Celgene, a Bristol-Myers Squibb Company, at the time of this analysis and may hold stock in Bristol Myers Squibb. Ashley Bonner and Yixie Zhang are employees of EVERSANA, which received funding from Bristol Myers Squibb to conduct the analyses. David G. Maloney reports scientific advisory board membership for A2 Biotherapeutics for which he receives consultancy fees; equity holdings in A2 Biotherapeutics for which he has stock options; honoraria from Amgen, BioLineRx, Bristol Myers Squibb, Celgene, a Bristol-Myers Squibb Company, Genentech, Gilead Sciences, Janssen, Juno Therapeutics, a Bristol-Myers Squibb Company, Kite Pharma, a Gilead Company, Legend Biotech, MorphoSys, Novartis, and Pharmacyclics; intellectual property patents with Juno, a Bristol-Myers Squibb Company (not licensed, no royalties); and research funding paid directly to his institution from Celgene, a Bristol-Myers Squibb Company, Juno Therapeutics, a Bristol-Myers Squibb Company, and Kite Pharma, a Gilead Company. John Kuruvilla reports consultancy from AbbVie, Bristol Myers Squibb, Gilead, Karyopharm, Merck, Roche, and Seattle Genetics; honoraria from Amgen, Antengene, AstraZeneca, Celgene, a Bristol-Myers Squibb Company, Gilead, Janssen, Karyopharm, Merck, Novartis, Pfizer, Roche, Seattle Genetics, and TG Therapeutics; and research funding from AstraZeneca, Janssen, and Roche.