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Authors
Sabol, Hayley M.
Anloague, Aric
Kaur, Japneet
Bustamante-Gomez, Cecile
Khan, Sharmin
Paxton, Bethany C.
Nester, Mattie R.
Hackney, Jillian
Diaz-delCastillo, Marta
Mann, Daniel
Stambough, Jeffrey B.
Barnes, C. Lowry
Ambrogini, Elena
Frontier, Alison
Ebetino, Frank H.
Naqvi, Syed
van Rhee, Frits
Wardell, Christopher P.
Drake, Matthew T.
Nookaew, Intawat
Schinke, Carolina
Zangari, Maurizio
Delgado-Calle, Jesus https://orcid.org/0000-0002-2083-2774
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Funding
Funding for this research was provided by:
National Institutes of Health (F31CA284655, P20GM125503, P20GM125503, P20GM125503, P20GM125503)
Neye Fonden and Aase og Ejnar Danielsens Fond (NA)
UAMS Winthrop P. Rockefeller Cancer Institute Voucher Program (NA)
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Article History
Received: 31 March 2025
Accepted: 12 August 2025
First Online: 22 August 2025
Declarations
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: All procedures involving animals were performed in accordance with the guidelines issued by the University of Arkansas for Medical Sciences Institutional Animal Care and Use Committee (IACUC) (protocol #2022200000489). Collection and de-identification of human bone samples for ex vivo studies were coordinated by the UAMS Winthrop P. Rockefeller Cancer Institute TBAPS and approved by the UAMS IRB (protocol # 262940). All study procedures were approved by the University of Arkansas for Medical Sciences (IRB # 260312) and the Mayo Clinic (IRB # 23-012399) institutional review board with a waiver of informed consent owing to the retrospective nature of the data. Trephine iliac crest bone marrow biopsies from patients with MGUS or newly diagnosed MM were retrieved from Danish histopathological biobanks under approval from the Danish National Committee on Biomedical Research Ethics (S-20190110). All human samples were collected and processed in accordance with the Declaration of Helsinki.
: The authors declare no competing interests.
