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Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation

Crossref DOI link: https://doi.org/10.1186/s40164-026-00771-7

Published Online: 2026-04-05

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zhang, Ruijia

Luo, Wenqin

Zhou, Qikai

Liang, Dongguo

Hao, Yuankai

Chen, Fan

Qiu, Yulin

Cao, Yixian

Shan, Zezhi

Zhang, Yu

Li, Qingguo

Cai, Sanjun

Luo, Dakui

Mo, Shaobo

Ma, Bin

Li, Xinxiang
Funding

Funding for this research was provided by:

National Natural Science Foundation of China
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Text and Data Mining valid from 2026-04-05

Version of Record valid from 2026-04-20
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Article History

Received: 9 September 2025

Accepted: 25 March 2026

First Online: 5 April 2026

Declarations

:

: Not applicable.

: Not applicable.

: The authors declare no competing interests.

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