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The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Published Online: 2021-04-20

Published Print: 2021-12

Authors

Barretto, Sharon Ann

Lasserre, Frederic

Huillet, Marine

Régnier, Marion

Polizzi, Arnaud

Lippi, Yannick

Fougerat, Anne

Person, Elodie

Bruel, Sandrine

Bétoulières, Colette

Naylies, Claire

Lukowicz, Céline

Smati, Sarra

Guzylack, Laurence

Olier, Maïwenn

Théodorou, Vassilia

Mselli-Lakhal, Laila

Zalko, Daniel

Wahli, Walter

Loiseau, Nicolas

Gamet-Payrastre, Laurence

Guillou, Hervé

Ellero-Simatos, Sandrine https://orcid.org/0000-0002-9282-1804
Funding

Funding for this research was provided by:

Joint Programming Initiative A healthy diet for a healthy life
License Information

Text and Data Mining valid from 2021-04-20

Version of Record valid from 2021-04-20
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Article History

Received: 2 February 2021

Accepted: 16 March 2021

First Online: 20 April 2021

Declarations

:

: All experiments involving mice were performed in a conventional laboratory animal room following the European Union guidelines for laboratory animal use and care. The project was approved by an independent ethics committee (CEEA-86 Toxcométhique) under the authorization number 2018062810452910. The animals were treated humanely with due consideration to the alleviation of distress and discomfort.

: Not applicable

: The authors declare that they have no competing interests.

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