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A cross-scale multimodal framework identifies clinically actionable immunotherapy biomarkers in melanoma through bulk to single-cell and spatial transcriptomics integration

Crossref DOI link: https://doi.org/10.1186/s40246-026-00919-w

Published Online: 2026-03-16

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Huoshen, Wuda

Yuan, Kun

Xiong, Junkai

Lin, Yilong

Yu, Wenjie

Xie, Yun

Yuan, Qian

Zhang, Xinyue

Dong, Changqing

Sun, Chen

Yi, Sha
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Text and Data Mining valid from 2026-03-16

Version of Record valid from 2026-04-23
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Article History

Received: 20 July 2025

Accepted: 15 January 2026

First Online: 16 March 2026

Declarations

:

: Ethics approval was not required for this study as tissue was collected from biopsy patients in which informed consent was already obtained by the study investigators.

: Not applicable.

: The authors declare no competing interests.

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